B7-2 Regulates Survival, Phenotype, and Function of APCs

Function of Apcs B7-2 Regulates Survival, Phenotype, And

B7-2 regulates survival, phenotype, and function of APCs.

The absence of B7-2-mediated costimulation protects NOD mice from the development of diabetes. Although the effects of B7-2 on T cell priming are well known, its impact on the function of APCs is not fully elucidated. We tested APC function and survival in mice lacking B7-2. A significant reduction in the phagocytic ability was observed in both splenic and pancreatic lymph node-associated dendr...

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function

Antigen-specific T cell activation requires the engagement of the T cell receptor (TCR) with antigen as well as the engagement of appropriate costimulatory molecules. The most extensively characterized pathway of costimulation has been that involving the interaction of CD28 and CTLA4 on the T cell with B7 (now termed B7-1) on antigen presenting cells. Recently, B7-2 a second costimulatory ligan...

B 7 - 2 Regulates Survival ,

Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets.

OBJECTIVE Type 2 diabetes is characterized by impaired insulin secretion in response to increased metabolic demand. This defect in beta-cell compensation seems to result from the interplay between environmental factors and genetic predisposition. Genome-wide association studies reveal that common variants in transcription factor 7-like 2 (TCF7L2) are associated with increased risk of type 2 dia...